A Case Study of Chimeric Antigen Receptor T Cell Function: Donor Therapeutic Differences in Activity and Modulation with Verteporfin.

Jiyong LiangDexing FangJoy GuminHinda NajemMoloud SooreshjaniRenduo SongAria SabbaghLing-Yuan KongJoseph DuffyIrina V BalyasnikovaSeth M PollackVinay K PuduvalliAmy B Heimberger

Published in: Cancers (2023)

These data propose CAR-induced autophagy as a mechanism counteracting CAR-induced trogocytosis and provide a new strategy to innovate high-performance CARs through pharmacological facilitation of T cell-induced tumor death.

Keyphrases

high glucose
diabetic rats
oxidative stress
drug induced
signaling pathway
endothelial cells
electronic health record
endoplasmic reticulum stress
big data
data analysis