Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.

Sarah GersingThea K SchulzeMatteo CagiadaAmelie SteinFrederick P RothKresten Lindorff-LarsenRasmus Hartmann-Petersen

Published in: Genome biology (2024)

In this study, we identify residues important for GCK metabolic stability and conformational dynamics. These residues could be targeted to modulate GCK activity, and thereby affect glucose homeostasis.

Keyphrases

high throughput
molecular dynamics simulations
single cell
cancer therapy
single molecule
type diabetes
blood pressure
antibiotic resistance genes
drug delivery
microbial community
wastewater treatment