Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2 specific T cells.

Catherine RiouGeorgia SchäferElsa du BruynRene T GoliathCari StekHuihui MouDeli HungKatalin Andrea WilkinsonRobert J Wilkinson

Published in: medRxiv : the preprint server for health sciences (2020)

In this proof of concept study, we show that SARS-CoV-2 T cell responses are easily detectable using a rapid whole blood assay requiring minimal blood volume. Such assay could represent a suitable tool to monitor adaptive immunity in vaccine trials.

Keyphrases

sars cov
high throughput
respiratory syndrome coronavirus
loop mediated isothermal amplification
flow cytometry
single cell