Induced production of a new antioxidant phenylpropanoid from Streptomyces sp. by protoplast formation/regeneration.

Enjuro HarunariNodoka YagoYasuhiro Igarashi

Published in: The Journal of antibiotics (2022)

Streptomyces sp. RD007556 regenerated from protoplast was found to produce p-coumaric acid 3,4-dihydroxybenzoate, propla acid (1) which is not observed in the wild-type strain. The structure of 1 was determined by NMR and MS analyses. Compound 1 showed antioxidant activities in DPPH and superoxide dismutase-like assays.

Keyphrases

wild type
oxidative stress
anti inflammatory
stem cells
magnetic resonance
mass spectrometry
multiple sclerosis
high resolution
ms ms
drug induced
endothelial cells