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A Modular Construction of Epidithiodiketopiperazines.

Thomas N SnaddonToya D ScaggsColin M PearsonJames W B Fyfe
Published in: Organic letters (2019)
Epidithiodiketopiperazines (ETPs) possess remarkably diverse biological activities and have attracted significant synthetic attention. The preparation of analogues is actively pursued; however, they are structurally challenging, and more direct and modular methods for their synthesis are desirable. To this end, the utility of a bifunctional triketopiperazine building block for the straightforward synthesis of ETPs is reported. A modular strategy consisting of enolate alkylation followed by site-selective nucleophile addition enables the concise synthesis of (±)-hyalodendrin and a range of analogues.
Keyphrases
  • molecular docking
  • working memory
  • structure activity relationship
  • molecularly imprinted
  • metal organic framework