Radon Exposure, Clonal Hematopoiesis, and Stroke Susceptibility in the Women's Health Initiative.
Kurtis M AnthonyJason M CollinsShelly-Ann M LoveJames D StewartSophie F BuchheitRahul GondaliaGary G SchwartzDavid Y HuangJaymie R MelikerZhenzhen ZhangAna BaracPinkal DesaiKathleen M HaydenMichael C HonigbergSiddhartha JaiswalPradeep NatarajanAlexander G BickCharles KooperbergJoAnn E MansonAlexander P ReinerEric A WhitselPublished in: Neurology (2024)
The robust elevation of radon-related risk of CHIP among postmenopausal women who develop incident cardioembolic stroke is consistent with a potential role of somatic genomic mutation in this societally burdensome form of cerebrovascular disease, although the mechanism has yet to be confirmed.
Keyphrases
- postmenopausal women
- bone mineral density
- atrial fibrillation
- copy number
- healthcare
- public health
- polycystic ovary syndrome
- cardiovascular disease
- quality improvement
- mental health
- high throughput
- circulating tumor cells
- health information
- pregnancy outcomes
- gene expression
- type diabetes
- metabolic syndrome
- dna methylation
- skeletal muscle
- breast cancer risk
- blood brain barrier
- genome wide