3C protease of enterovirus 71 cleaves promyelocytic leukemia protein and impairs PML-NBs production.

Zhuoran LiYa'ni WuHui LiWenqian LiJuan TanWentao Qiao

Published in: Virology journal (2021)

EV71 3C cleaves PMLIV at Q430-A431 and Q444-S445. Cleavage reduces the antiviral function of PML and decomposes the formation of PML-NBs, which is conducive to virus replication.

Keyphrases

acute myeloid leukemia
bone marrow
protein protein
dna binding
amino acid
binding protein
small molecule