Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis.

Yongchang LiErliang KongRuifeng DingRuitong ChuJinfang LuMengqiu DengTong HuaMei YangHaowei WangDashuang ChenHonghao SongHuawei WeiPing ZhangChaofeng HanHong-Bin Yuan

Published in: CNS neuroscience & therapeutics (2024)

Hyperglycemia induces metabolic reprogramming and inflammatory activation in microglia through the regulation of Sirt3 transcription and degradation. This novel mechanism identifies Sirt3 as a potential drug target for treating DNP.

Keyphrases

neuropathic pain
oxidative stress
diabetic rats
spinal cord
spinal cord injury
ischemia reperfusion injury
type diabetes
inflammatory response
cell proliferation
high glucose
signaling pathway
drug induced
transcription factor
high intensity
emergency department
climate change
adverse drug
electronic health record