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The post-COVID-19 population has a high prevalence of cross-reactive antibodies to spikes from all Orthocoronavirinae genera.

Gagandeep SinghAnass AbbadGiulio KleinerKomal SrivastavaCharles Gleasonnull nullJuan Manuel CarreñoViviana SimonFlorian Krammer
Published in: mBio (2023)
As demonstrated by severe acute respiratory syndrome coronavirus 2, coronaviruses pose a significant pandemic threat. Here, we show that coronavirus disease 2019 mRNA vaccination can induce significant levels of cross-reactive antibodies against diverse coronavirus spike proteins. While these antibodies are binding antibodies that likely have little neutralization capacity and while their contribution to cross-protection is unclear, it is possible that they may play a role in protection from progression to severe disease with novel coronaviruses.
Keyphrases
  • sars cov
  • respiratory syndrome coronavirus
  • coronavirus disease
  • binding protein