The significance of maternal blood pregnancy-associated plasma protein A (PAPP-A) and free beta-subunit of human chorionic gonadotropin (β-hCG) levels for the risk assessment of fetal trisomy 18 during the first prenatal testing between 11 and 13+6 weeks of pregnancy.

Katarzyna Ziolkowska Kinga Toboła-WróbelPiotr DydowiczSebastian ZurawskiBeata NowakowskaEwa Wysocka

Published in: Ginekologia polska (2021)

Maternal free β-hCG MoM was found to change parallelly to fetal NT widening in case of trisomy 18 diagnosis. Maternal β-hCG and PAPP-A MoM results presented less then 0.2 might be used independently of NT widening in fetus for trisomy 18 risk evaluation. Above 0.2 for PAPP-A and β-hCG MoMs, fetal NT measurement was an requirment.

Keyphrases

pregnancy outcomes
birth weight
pregnant women
risk assessment
preterm birth
gestational age
endothelial cells
small molecule
protein protein
protein kinase