Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries.

Yanyu LiangMilton PividoriAni ManichaikulAbraham A PalmerNancy J CoxHeather E WheelerHae Kyung Im

Published in: Genome biology (2022)

We show that PTRS has a significantly higher portability (Wilcoxon p=0.013) in the African-descent samples where the loss of performance is most acute with better performance than PRS when used in combination.

Keyphrases

liver failure
gene expression
rna seq
intensive care unit
dna methylation
hepatitis b virus