RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.

Hannelore P Van EeckhoutteChantal DonovanRichard Y KimThomas M ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G HansbroYves DondelingerTom DelangheAllison M BealBrad GeddesJohn BertinTom Vanden BergheJoyceline De VolderTania MaesPeter VandenabeeleBart M VanaudenaerdeDieter Deforce Sonja ŠkevinFilip Van NieuwerburghFien M VerhammeGuy F JoosSobia IdreesHerbert B SchillerAli Oender YildirimAlen FaizMathieu J M BertrandGuy G O BrussellePhilip M HansbroKen R Bracke

Published in: The European respiratory journal (2023)

RIPK1 kinase inhibition is protective in experimental models of COPD and may represent a novel promising therapeutic approach.

Keyphrases

cell death
chronic obstructive pulmonary disease
lung function
protein kinase
oxidative stress
tyrosine kinase
cell proliferation