Comparative analysis of humoral immune responses and pathologies of BALB/c and C57BL/6 wildtype mice experimentally infected with a highly virulent Rodentibacter pneumotropicus (Pasteurella pneumotropica) strain.

Juliane FornefettJaqueline KrauseKristin KloseFelix FingasRayk HassertLaurentiu BengaThomas GrunwaldUwe MüllerWieland SchrödlChristoph Georg Baums

Published in: BMC microbiology (2018)

R. pneumotropicus JF4Ni is a highly virulent strain causing severe pneumonia and septicemia after intranasal infection of C57BL/6 and BALB/c mice. Persisting infections in the two mice strains are associated with Th1 and Th2 immune responses, respectively, and differences in the bacterial burden of the lung. The described model is ideally suited for future vaccination studies using the natural host.

Keyphrases

immune response
high fat diet induced
toll like receptor
type diabetes
insulin resistance
wild type
risk factors
drug induced
transition metal