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Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder.

Jaime Ramos-CejudoJune K CorriganChunlei ZhengKaitlin N SwinnertonSean R JacobsonJennifer LaRebecca A BetenskyRicardo S OsorioSharon MadanesNunzio PomaraDan IosifescuMary BrophyNhan V DoNathanael R Fillmore
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
We studied whether antidepressant use was associated with future dementia risk. We specifically focused on patients after their first-ever diagnosis of depression. We used IPW Cox models with time-varying covariates and a large observation window. Our study did not identify an effect of antidepressant use on dementia risk. A risk reduction was observed in female patients, but the number of cases was small.
Keyphrases
  • major depressive disorder
  • end stage renal disease
  • bipolar disorder
  • ejection fraction
  • mild cognitive impairment
  • newly diagnosed
  • cognitive impairment
  • prognostic factors
  • depressive symptoms
  • current status