PGRS domain structures: Doomed to sail the mycomembrane.

Published in: PLoS pathogens (2022)

The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.

Keyphrases

artificial intelligence
machine learning
big data
deep learning
mycobacterium tuberculosis
high resolution
low grade
amino acid
binding protein
mass spectrometry