Assessing the Role of 98 Established Loci for BMI in American Indians.

Yunhua L MullerRobert L HansonPaolo PiaggiPeng ChenGregory WiessnerChidinma OkaniGraham SkeltonSayuko KobesWen-Chi HsuehWilliam C KnowlerClifton BogardusLeslie J Baier

Published in: Obesity (Silver Spring, Md.) (2019)

In aggregate, European-derived lead SNPs had a notable effect on BMI in Pima Indians. Polygenic obesity in this population manifests strongly in childhood and adolescence and persists throughout much of adult life.

Keyphrases

weight gain
body mass index
genome wide
insulin resistance
metabolic syndrome
genome wide association
childhood cancer
weight loss
depressive symptoms
type diabetes
high fat diet induced
dna methylation
physical activity