Hybrid peeling for fast and accurate calling, phasing, and imputation with sequence data of any coverage in pedigrees.

Andrew WhalenRoger Ros-FreixedesDavid L WilsonGregor GorjancJohn M Hickey

Published in: Genetics, selection, evolution : GSE (2018)

We believe that this algorithm will enable the generation of low cost and high accuracy whole-genome sequence data in many pedigreed populations. We make this algorithm available as a standalone program called AlphaPeel.

Keyphrases

low cost
machine learning
electronic health record
deep learning
big data
quality improvement
high resolution
healthcare
neural network
artificial intelligence
amino acid
data analysis
mass spectrometry
genetic diversity
health insurance