Genetic defects in hematopoietic transcription factors and predisposition to acute lymphoblastic leukemia.
Yoshihiro GochoJun J YangPublished in: Blood (2019)
Recent genome-wide studies have revealed a plethora of germline variants that significantly influence the susceptibility to acute lymphoblastic leukemia (ALL), thus providing compelling evidence for genetic inheritance of this blood cancer. In particular, hematopoietic transcription factors (eg, ETV6, PAX5, IKZF1) are most frequently implicated in familial ALL, and germline variants in these genes confer strong predisposition (albeit with incomplete penetrance). Studies of germline risk factors for ALL provide unique insights into the molecular etiology of this leukemia.
Keyphrases
- acute lymphoblastic leukemia
- genome wide
- copy number
- mitochondrial dna
- transcription factor
- bone marrow
- dna methylation
- dna repair
- allogeneic hematopoietic stem cell transplantation
- case control
- genome wide identification
- papillary thyroid
- acute myeloid leukemia
- early onset
- dna binding
- gene expression
- single molecule
- lymph node metastasis