Replication origin location might contribute to genetic variability in Trypanosoma cruzi.

Christiane Bezerra de AraujoJulia Pinheiro Chagas da CunhaDavi Toshio InadaJeziel DamascenoAlex Ranieri Jerônimo LimaPriscila HiraiwaCatarina MarquesEvonnildo GonçalvesMilton Yutaka Nishiyama-JuniorRichard McCullochMaria Carolina Elias

Published in: BMC genomics (2020)

These findings suggest a scenario where collisions between DNA replication and transcription are frequent, leading to increased genetic variability, as seen by the increase SNP levels at chromosome subtelomeres and in DGF-1 genes containing putative origins.

Keyphrases

genome wide
trypanosoma cruzi
copy number
dna methylation
transcription factor
gene expression
bioinformatics analysis
genetic diversity
genome wide analysis