Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns.

Hudson P SantosAdam E EnggasserJeliyah ClarkKyle RoellVasyl ZhabotynskyWilliam Adam GowerDiana YanniNou Gao YangLisa WashburnSemsa GogcuCarmen J MarsitKarl KubanT Michael O'SheaRebecca C Fry

Published in: BMC biology (2023)

Distinct methylation patterns were observed between male and female children born extremely premature, and keratinocyte differentiation pathways were enriched in the placenta. These findings provide new insights into the epigenetic mechanisms underlying sexually dimorphic health outcomes among extremely premature infants.

Keyphrases

low birth weight
gestational age
dna methylation
genome wide
preterm infants
healthcare
preterm birth
public health
young adults
gene expression
pregnant women
health information
health promotion
risk assessment