METTL3 is essential for small intestinal epithelial proliferation via regulation of growth factor signaling including KRAS.

Charles H DananKaitlyn E NaughtonKatharina E HayerSangeevan VellappanEmily A McMillanYusen ZhouRina MatsudaShaneice K NettlefordKay KatadaLouis R ParhamXianghui MaAfrah ChowdhuryBenjamin J WilkinsPremal ShahMatthew D WeitzmanKathryn E Hamilton

Published in: bioRxiv : the preprint server for biology (2023)

METTL3 deletion leads to cell death in proliferating small intestinal epithelium associated with decreased translation of growth factor transducers.

Keyphrases

growth factor
cell death
signaling pathway
cell cycle arrest
wild type