Copolymer Micelle-administered Melatonin Ameliorates Hyperosmolarity-induced Ocular Surface Damage through Regulating PINK1-mediated Mitophagy.

Jing XuPeng ChenGuangfen ZhaoSusu WeiQiqi LiChuanlong GuoQilong CaoXianggen WuGuohu Di

Published in: Current eye research (2022)

Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity-induced ocular surface damage via PINK1-mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.

Keyphrases

high glucose
diabetic rats
oxidative stress
mouse model
nlrp inflammasome
combination therapy
drug delivery
smoking cessation