Boronic Acid/Palladium Hybrid Catalysis for Regioselective O -Allylation of Carbohydrates.

Novel imidazole-containing boronic acid and palladium hybrid catalysis for regioselective O -allylation of carbohydrates has been developed. This catalytic process enables the introduction of a useful allyl functional group into the equatorial hydroxy group of cis -1,2-diols of various carbohydrates with low catalyst loading and excellent regioselectivities. This is the first report on hybrid catalysis in combination with a Lewis base-containing boronic acid and a transition metal complex.