Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals.
Zhijun MengZhen ZhangJianli ZhaoCaihong LiuPeng YaoLing ZhangDina XieWayne Bond LauJumpei TsukudaTheodore A ChristopherBernard LopezDi ZhuDemin LiuJohn Ry ZhangErhe GaoHarry IschiropoulosWalter J KochXin-Liang MaYajing WangPublished in: Circulation (2023)
and resultant signal complex dissociation results in cardiac insulin/adiponectin resistance in the prediabetic heart, contributing to ischemic heart failure progression. Early interventions preserving Cav3-centered signalsome integrity is an effective novel strategy against diabetic exacerbation of ischemic heart failure.
Keyphrases
- heart failure
- left ventricular
- insulin resistance
- type diabetes
- ischemia reperfusion injury
- cardiac resynchronization therapy
- atrial fibrillation
- metabolic syndrome
- acute heart failure
- chronic obstructive pulmonary disease
- adipose tissue
- cerebral ischemia
- physical activity
- high fat diet
- skeletal muscle
- intensive care unit
- blood brain barrier
- climate change
- electron transfer