Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems.
Suliman KhanPengfei DuanLunguang YaoHong-Wei HouPublished in: International journal of genomics (2018)
Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.
Keyphrases
- mental health
- healthcare
- public health
- bipolar disorder
- genome wide
- risk factors
- physical activity
- health information
- sleep quality
- endothelial cells
- human health
- gene expression
- health promotion
- dna methylation
- major depressive disorder
- multiple sclerosis
- young adults
- blood brain barrier
- subarachnoid hemorrhage
- transcription factor