Reduced dose folinic acid rescue after rapid high-dose methotrexate clearance is not associated with increased toxicity in a pediatric cohort.

Riitta Niinimäki Henri AarnivalaJoanna BanerjeeTytti PokkaKaisa VepsäläinenArja H Harila-Saari

Published in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)

A pharmacokinetically guided FA rescue of one or two 15 mg/m2 doses of FA following HD-MTX courses with rapid MTX clearance results in a shorter hospitalization without an increase in toxic effects.

Keyphrases

high dose
low dose
stem cell transplantation
loop mediated isothermal amplification
oxidative stress