IgE to cross-reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins.
Ekaterina PotapovaSalvatore TripodiValentina PanettaStephanie DramburgRoberto BernardiniCarlo CaffarelliAntonella CasaniRosa CervoneLoredana ChiniPasquale ComberiatiGiovanna De CastroMichele Miraglia Del GiudiceIride Dello IaconoAndrea Di Rienzo BusincoMarcella GallucciArianna GiannettiViviana MoscheseIfigenia SfikaElena VarinRiccardo AseroAnnamaria BianchiMauro CalvaniTullio FredianiFrancesco MacrìNunzia MaielloFrancesco ParavatiUmberto PelosiDiego PeroniGiuseppe PingitoreMariangela ToscaAnna Maria ZicariGiampaolo Riccinull nullGerald ReeseLinus GrabenhenrichKatja IckeArmin GrüblChristoph MüllerFred ZeppAntje SchusterUlrich WahnSusanne LauThomas KeilPaolo Maria MatricardiPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2024)
Our results contribute to dissect the immunological origins, onset, evolution and risk factors of CCD-sIgE response in childhood, and raise the hypothesis that group 1 and/or 4 allergen molecules of grass pollen are major inducers of these antibodies through an antigen-specific, T-B cell cognate interaction.