Electronic control of drug release from gauze or cellulose acetate fibres for dermal applications.
Ana Catarina BaptistaMiguel BritoAna MarquesIsabel M M FerreiraPublished in: Journal of materials chemistry. B (2021)
Electronic controlled drug release from fibres was studied using ibuprofen as a model drug, one of the most popular analgesics, to impregnate gauze and cellulose acetate (CA) membranes. Conductivity in the range of 1-10 mS cm-1 was obtained in polypyrrole (Ppy) functionalised gauze and CA fibres, providing voltage-controlled drug release in a system consisting of Ppy/Ibuprofen/Ppy membranes and an Ag electrode. SEM images evidenced the Ppy adhesion to fibres and Micro Raman spectra proved drug incorporation and release. A small wound adhesive built with these membranes retains ibuprofen at 1.5 V and quickly releases it when -0.5 V is applied.
Keyphrases
- drug release
- drug delivery
- postoperative pain
- mass spectrometry
- multiple sclerosis
- adverse drug
- drug induced
- deep learning
- escherichia coli
- quantum dots
- density functional theory
- pseudomonas aeruginosa
- staphylococcus aureus
- cystic fibrosis
- machine learning
- candida albicans
- solid state
- electronic health record
- high resolution
- silver nanoparticles
- aqueous solution