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Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Chengcheng LiuLaura J JankeJun J YangWilliam E EvansJohn D SchuetzMary V Relling
Published in: Cancer chemotherapy and pharmacology (2017)
We showed that both Tpmt and Mrp4 influence mercaptopurine disposition and toxicity.
Keyphrases
  • oxidative stress
  • genome wide
  • copy number
  • oxide nanoparticles
  • gene expression
  • genome wide identification
  • genome wide analysis