Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells.

Lufeng ZhengQianqian GuoChenxi XiangShijia LiuYuzhang JiangLanlan GaoHaiwei NiTing WangQiong ZhaoHai LiuYingying XingYaohui WangXiaoman LiTao Xi

Published in: Journal of hematology & oncology (2019)

Our results uncover the mechanism through which ceRNET_CC is regulated, identify novel roles for the six2/ceRNET_CC axis in regulating the stemness of breast cancer cells, and propose the possibility of targeting the six2/ceRNET_CC axis to inhibit breast cancer stem cell (CSC) traits.

Keyphrases

breast cancer cells
cancer stem cells
stem cells
transcription factor
epithelial mesenchymal transition
gene expression
genome wide
cancer therapy
oxidative stress
heat shock