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Loss of β-catenin reveals a role for glutathione in regulating oxidative stress during cholestatic liver disease.

Oluwashanu BalogunDaniel ShaoMatthew CarsonThalia KingKaris KosarRong ZhangGang ZengPamela CornuetChhavi GoelElizabeth LeeGarima PatelEva BrooksSatdarshan Paul MongaSilvia LiuKari Nejak-Bowen
Published in: Hepatology communications (2024)
Loss of β-catenin leads to increased cellular injury and cell death during cholestasis through failure to neutralize oxidative stress, which may contribute to the pathology of this disease.
Keyphrases
  • oxidative stress
  • cell death
  • epithelial mesenchymal transition
  • cell proliferation
  • dna damage
  • liver injury
  • ischemia reperfusion injury
  • diabetic rats
  • drug induced
  • induced apoptosis
  • liver fibrosis