Loss of β-catenin reveals a role for glutathione in regulating oxidative stress during cholestatic liver disease.
Oluwashanu BalogunDaniel ShaoMatthew CarsonThalia KingKaris KosarRong ZhangGang ZengPamela CornuetChhavi GoelElizabeth LeeGarima PatelEva BrooksSatdarshan Paul MongaSilvia LiuKari Nejak-BowenPublished in: Hepatology communications (2024)
Loss of β-catenin leads to increased cellular injury and cell death during cholestasis through failure to neutralize oxidative stress, which may contribute to the pathology of this disease.