Alpha-defensin as a diagnostic tool in revision total knee arthroplasties with unexpected positive intraoperative cultures and unexpected culture negative intraoperative cultures.
Sebastian SimonBernhard J H FrankAlexander AichmairMartin DominkusJennyfer A MittererSusana Gardete HartmannMichael KasparekJochen G HofstätterPublished in: Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA (2022)
AD showed a solid diagnostic performance in infected and non-infected revisions, and it provided an additional value in the diagnosis of UPIC and UNIC associated to rTKAs. Pathogen virulence as well as antibiotic resistance pattern may have an effect on AD levels. Centrifugation of synovial fluid had no influence on ADLF results.