Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.
Kazuhiro NishiyamaTakuro Numaga-TomitaYasuyuki FujimotoTomohiro TanakaChiemi ToyamaAkiyuki NishimuraTomohiro YamashitaNaoya MatsunagaSatoru KoyanagiYasu-Taka AzumaYuko IbukiKoji UchidaShigehiro OhdoMotohiro NishidaPublished in: British journal of pharmacology (2019)
These results indicate a common mechanism underlying induction of systemic tissue wasting by doxorubicin. They also suggest that ibudilast could be repurposed to prevent muscle toxicity caused by anticancer drugs or passive smoking.