The effects of letrozole-induced maternal hyperandrogenism on sexual behaviors, testicular histology, and serum biochemical traits in male offspring rats: An experimental study.

Zahra ShaabanAmin DerakhshanfarMohammad Reza Jafarzadeh ShiraziMohammad Javad ZamiriJavad MoayediMahjoob VahediAbouzar Valizadeh

Published in: International journal of reproductive biomedicine (2023)

Maternal exposure to letrozole can adversely affect the reproductive and metabolic performance of male offspring rats, suggesting an incomplete sex differentiation.

Keyphrases

polycystic ovary syndrome
high fat diet
birth weight
pregnancy outcomes
insulin resistance
early breast cancer
high glucose
diabetic rats
genome wide
dna methylation
type diabetes
drug induced
pregnant women
metabolic syndrome
body mass index
oxidative stress
germ cell
endothelial cells
gestational age