The earlier the better or the later the better: optimal timing of fetal reduction from twins to singleton.

Second trimester reduction of twins is associated with an increased rate of prematurity and adverse neonatal outcomes compared with late first trimester reduction, without increasing the procedure-related complications. Technological advances in earlier sonographic diagnosis and more frequent use of CVS have allowed earlier detection of fetal anatomic and chromosomal abnormalities. Therefore, efforts should be made to complete early fetal assessment to allow reduction during the first trimester. This article is protected by copyright. All rights reserved.