Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies.

Carolin ZitzmannChristopher DaechertBianca SchmidHilde van der SchaarMartijn van HemertAlan S PerelsonFrank J M van KuppeveldRalf BartenschlagerMarco BinderLars Kaderali

Published in: bioRxiv : the preprint server for biology (2022)

drug treatment analysis suggests that targeting viral proteases involved in polyprotein cleavage, in combination with viral RNA replication, may represent promising drug targets with broad-spectrum antiviral activity.

Keyphrases

sars cov
adverse drug
cancer therapy
emergency department
drug delivery
replacement therapy