Development of a Comprehensive Gene Signature Linking Hypoxia, Glycolysis, Lactylation, and Metabolomic Insights in Gastric Cancer through the Integration of Bulk and Single-Cell RNA-Seq Data.
Xiangqian ZhangYun LiYongheng ChenPublished in: Biomedicines (2023)
The innovative HGLRG signature demonstrates efficacy in predicting survival and providing a practical clinical model for gastric cancer. The HGLRG signature reflects the internal metabolism, drug responsiveness, and immune microenvironment components of gastric cancer and is expected to boost patients' response to targeted therapy and immunotherapy.
Keyphrases
- rna seq
- single cell
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- high throughput
- peritoneal dialysis
- prognostic factors
- endothelial cells
- emergency department
- copy number
- genome wide
- big data
- gene expression
- patient reported outcomes
- patient reported
- drug induced
- artificial intelligence