BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma.

Yan-Ling ChenXiao-Lu LiGen LiYan-Fang TaoRan ZhuoHai-Bo CaoWan-Yan JiaoZhi-Heng LiZhen-Hong ZhuFang FangYi XieXin-Mei LiaoDi WuHai-Rong WangJuan-Juan YuSi-Qi JiaYang YangChen-Xi FengPeng-Cheng YangXiao-Dong FeiJian-Wei WangYun-Yun XuGuang-Hui QianZi-Mu ZhangJian Pan

Published in: Cell & bioscience (2022)

GNE987 destroyed the abnormal transcriptional regulation of oncogenes in NB by downregulating BRD4, which could be a potential therapeutic candidate for NB.

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