Caveolin-3 loss linked with the P104L LGMD-1C mutation modulates skeletal muscle mTORC1 signalling and cholesterol homeostasis.

Dinesh S ShahRaid B NisrGabriela Krasteva-ChristHarinder S Hundal

Published in: Journal of cachexia, sarcopenia and muscle (2023)

mutation impairs mTORC1 activation and protein synthetic capacity in skeletal muscle cells, which may be linked to disturbances in lysosomal cholesterol trafficking and contribute to the pathology of LGMD-1C.

Keyphrases

skeletal muscle
low density lipoprotein
induced apoptosis
insulin resistance
cell cycle arrest
protein protein
adipose tissue
type diabetes
signaling pathway
oxidative stress
binding protein
metabolic syndrome
pi k akt