The novel antidepressant ketamine enhances dentate gyrus proliferation with no effects on synaptic plasticity or hippocampal function in depressive-like rats.

Henrik MichaëlssonMats AnderssonJohan SvenssonLars KarlssonJohan EhnGeorgia CulleyAnders EngströmNicklas BergströmParthenia SavvidiHans-Georg KuhnEric HanseHenrik Seth

Published in: Acta physiologica (Oxford, England) (2018)

We find limited effects of ketamine on hippocampal glutamatergic transmission. Instead, alterations in dentate gyrus proliferation could explain the antidepressant effects of ketamine.

Keyphrases

major depressive disorder
pain management
signaling pathway
bipolar disorder
cerebral ischemia
temporal lobe epilepsy
brain injury
blood brain barrier