Hyaluronan synthesis inhibition normalizes ethanol-enhanced hepatic stellate cell activation.

Manasi KotulkarDakota R RobartsKristi Lin-RahardjaTara McQuillanJordan SurgnierSarah E TagueMaciej CzerwinskiKatie L DennisMichele T Pritchard

Published in: Alcohol (Hanover, York County, Pa.) (2023)

These data show that ethanol augments HSC activation through HA synthesis and enhances hepatic profibrogenic features. Therefore, targeting HSC HA production could potentially attenuate liver disease in ALD patients.

Keyphrases

end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
single cell
prognostic factors
electronic health record
cell therapy
machine learning
big data
bone marrow
mesenchymal stem cells