Assessment of BRAF V600E (VE1) immunochemistry for the detection of BRAF V600E mutation in non-small cell lung carcinoma cytology specimens.

Ashley GarciaMaria Del Mar Rivera RolonBedia BarkohWei ChenRajyalakhsmi LuthraSinchita Roy-Chowdhuri

Published in: Cancer cytopathology (2022)

This study suggests that BRAF V600E IHC can be used reliably to screen NSCLC cytology specimens, and negative results strongly indicate the absence of a BRAF V600E mutation. Having a low threshold for equivocal staining is recommended with molecular confirmation of BRAF V600E for any cases demonstrating weak and/or focal cytoplasmic staining.

Keyphrases

metastatic colorectal cancer
fine needle aspiration
wild type
high grade
small cell lung cancer
ultrasound guided
single cell
high throughput
cell therapy
single molecule
real time pcr