Applying 3D ED/MicroED workflows toward the next frontiers.
Mahira F AragonSarah E J BowmanChun Hsing ChenM Jason de la CruzDaniel A DecatoEdward T EngKristen M FlattSahil GulatiYuchen LiCharles J LombaBrandon MercadoJessalyn MillerLukáš PalatinusWilliam J RiceDavid Geoffrey WatermanChristina M ZimanyiPublished in: Acta crystallographica. Section C, Structural chemistry (2024)
We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED), as discussed during a symposium at the National Center for CryoEM Access and Training housed at the New York Structural Biology Center. This snapshot describes cutting-edge developments in various facets of the field and identifies potential avenues for continued progress. Key sections discuss instrumentation access, research applications for small molecules and biomacromolecules, data collection hardware and software, data reduction software, and finally reporting and validation. 3D ED/MicroED is still early in its wide adoption by the structural science community with ample opportunities for expansion, growth, and innovation.