Login / Signup

2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives.

Takahiro ShiraiMotomu KanaiYoichiro Kuninobu
Published in: Organic letters (2018)
We developed 2-position-selective, direct C-H trifluoromethylation, pentafluoroethylation, and heptafluoropropylation of quinoline derivatives. Regioselective transformation was achieved without derivatization of the quinolines. The reaction proceeded at room temperature with high functional group tolerance, even in gram scale. Notably, the reaction was applicable to substrates containing a functional group sensitive to oxidation and a drug molecule.
Keyphrases