2-Position-Selective C-H Perfluoroalkylation of Quinoline Derivatives.
Takahiro ShiraiMotomu KanaiYoichiro KuninobuPublished in: Organic letters (2018)
We developed 2-position-selective, direct C-H trifluoromethylation, pentafluoroethylation, and heptafluoropropylation of quinoline derivatives. Regioselective transformation was achieved without derivatization of the quinolines. The reaction proceeded at room temperature with high functional group tolerance, even in gram scale. Notably, the reaction was applicable to substrates containing a functional group sensitive to oxidation and a drug molecule.
Keyphrases
- room temperature
- molecular docking
- ionic liquid
- ms ms
- electron transfer
- high performance liquid chromatography
- hydrogen peroxide
- structure activity relationship
- liquid chromatography
- tandem mass spectrometry
- mass spectrometry
- gas chromatography
- nitric oxide
- emergency department
- molecular dynamics simulations
- drug induced
- high resolution
- solid phase extraction