Login / Signup

Astragalus polysaccharide attenuates diabetic nephropathy by reducing apoptosis and enhancing autophagy through activation of Sirt1/FoxO1 pathway.

Yanmei XuChen XuJie HuangChuanwen XuYan Xiong
Published in: International urology and nephrology (2024)
APS mitigated DN under hyperglycemic conditions by activating the Sirt1/FoxO1 autophagy pathway, suggesting that APS is a promising agent for DN treatment.
Keyphrases
  • signaling pathway
  • oxidative stress
  • diabetic nephropathy
  • endoplasmic reticulum stress
  • cell death
  • pi k akt
  • cell cycle arrest
  • transcription factor
  • ischemia reperfusion injury
  • cell proliferation