Blockade of angiotensin AT1 receptors prevents arterial remodelling and stiffening in iron-overloaded rats.

Helbert Gabriel FidelisJandinay Gonzaga Alexandre MageskiSusana Curry Evangelista GoesTatiani BotelhoVinicius Bermond MarquesRenata Andrade ÁvilaLeonardo Dos Santos

Published in: British journal of pharmacology (2020)

Losartan prevented the structural and functional indices of aortic stiffness in iron-overloaded rats, implying that inhibition of the renin-angiotensin system would limit the vascular remodelling in chronic iron-overload.

Keyphrases

iron deficiency
angiotensin ii
left ventricular
mouse model
angiotensin converting enzyme
coronary artery
atrial fibrillation
pulmonary arterial hypertension