Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice.

Si-Wei WangHao ShengYong-Feng BaiYuan-Yuan WengXue-Yu FanLi-Jun Lou Feng Zhang

Published in: Nutrition & diabetes (2020)

PGC-1α-mediated mitochondrial biogenesis plays a vital role in the mitigation of hepatic steatosis treated by NHP. Our result suggests that NHP is a good candidate to be dietary supplement for the auxiliary treatment of NAFLD.

Keyphrases

high fat diet
insulin resistance
skeletal muscle
oxidative stress
adipose tissue
climate change
high fat diet induced
type diabetes
metabolic syndrome
mouse model
wild type