The Efficacy and Safety of Bedaquiline in the Treatment of Pulmonary Tuberculosis Patients: A Systematic Review and Meta-Analysis.

Enyu TongQian WuYiming ChenZhengwei LiuMingwu ZhangYelei ZhuKunyang WuJunhang PanJianmin Jiang

Published in: Antibiotics (Basel, Switzerland) (2023)

Data from both RCTs and NRSs support the efficacy of BDQ for the treatment of pulmonary tuberculosis. However, the use of BDQ is associated with a higher incidence of cardiotoxicity and serious adverse events. Comparative data on efficacy and safety are limited, and further confirmation is required, due to potential bias and discrepancies in the available studies.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
end stage renal disease
chronic kidney disease
ejection fraction
drug resistant
multidrug resistant
big data
risk factors
machine learning
combination therapy
risk assessment
replacement therapy