Fabrication of a Flexible and Stretchable Nanostructured Gold Electrode Using a Facile Ultraviolet-Irradiation Approach for the Detection of Nitric Oxide Released from Cells.
Xu ZhaoKeqing WangBo LiChao WangYongqi DingChangqing LiLanqun MaoYu-Qing LinPublished in: Analytical chemistry (2018)
We developed a simple and environmentally friendly ultraviolet (UV)-irradiation-assisted technique to fabricate a stretchable, nanostructured gold film as a flexible electrode for the detection of NO release. The flexible gold film endows the electrode with desirable electrochemical stability against mechanical deformation, including bending to different curvatures and bearing repeated bending circumstances (200 times). The flexible nanostructured gold electrodes can catalyze NO oxidation at 0.85 V (as opposed to Ag/AgCl) and detect NO within a wide linearity in the range of 10 nM to 1.295 μM. Its excellent NO-sensing ability and its stretchability together with its biocompatibility allows the electrode to electrochemically monitor NO release from mechanically sensitive HUVECs in both their unstretched and stretched states. This result paves the way for an effective and easily accessible platform for designing stretchable and flexible electrodes and opens more opportunities for sensing chemical-signal molecules released from cells or other biological samples during mechanical stimulation.
Keyphrases
- solid state
- carbon nanotubes
- reduced graphene oxide
- induced apoptosis
- nitric oxide
- cell cycle arrest
- label free
- gold nanoparticles
- silver nanoparticles
- quantum dots
- hydrogen peroxide
- photodynamic therapy
- loop mediated isothermal amplification
- signaling pathway
- high throughput
- endoplasmic reticulum stress
- room temperature
- oxidative stress
- mass spectrometry
- radiation therapy
- cell proliferation
- highly efficient
- low cost
- ionic liquid
- tissue engineering
- molecularly imprinted