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Race/ethnicity and underlying disease influences hematopoietic stem/progenitor cell mobilization response: A single center experience.

Chukwuemeka UzokaLi C LiuYoungmin ParkYuankai LinPritesh PatelSally Campbell-LeeKaren SweissXinhe WangElena TepakDavid PeaceSantosh SarafDamiano RondelliNadim Mahmud
Published in: Journal of clinical apheresis (2021)
Our study shows that race/ethnicity and diagnostic group differences influenced CD34+ cell mobilization response across donor types. Interestingly, autologous MM donors with the aid of plerixafor displayed comparable CD34 yields to allogeneic donors. Even though both MM and non-MM donors received plerixafor, non-MM donors had significantly lower CD34 yields among AA and O donors but not in W donors. Larger studies would be required to validate the role of diagnostic groups and race/ethnicity interactions.
Keyphrases
  • kidney transplantation
  • bone marrow
  • cell therapy
  • low dose
  • high dose